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Dissecting the genetic architecture of F-1 hybrid sterility in house mice

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00383223" target="_blank" >RIV/68378050:_____/12:00383223 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >10.1111/j.1558-5646.2012.01684.x</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dissecting the genetic architecture of F-1 hybrid sterility in house mice

  • Original language description

    Hybrid sterility as a postzygotic reproductive isolation mechanism has been studied for over 80 years, yet the first identifications of hybrid sterility genes in Drosophila and mouse are quite recent. To study the genetic architecture of F-1 hybrid sterility between young subspecies of house mouse Mus m. domesticus and M. m. musculus, we conducted QTL analysis of a backcross between inbred strains representing these two subspecies and probed the role of individual chromosomes in hybrid sterility using the intersubspecific chromosome substitution strains. We provide direct evidence that the asymmetry in male infertility between reciprocal crosses is conferred by the middle region of M. m. musculus Chr X, thus excluding other potential candidates such asY, imprinted genes, and mitochondrial DNA. QTL analysis identified strong hybrid sterility loci on Chr 17 and Chr X and predicted a set of interchangeable autosomal loci, a subset of which is sufficient to activate the Dobzhansky-Muller

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/LD11079" target="_blank" >LD11079: New Mouse Models for Studies on Biomedical Complex Traits and Human Diseases and for Systems Genetics</a><br>

  • Continuities

    Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Evolution

  • ISSN

    0014-3820

  • e-ISSN

  • Volume of the periodical

    66

  • Issue of the periodical within the volume

    11

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    15

  • Pages from-to

    3321-3335

  • UT code for WoS article

    000310477600002

  • EID of the result in the Scopus database