Dissecting the genetic architecture of F-1 hybrid sterility in house mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00383223" target="_blank" >RIV/68378050:_____/12:00383223 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1558-5646.2012.01684.x" target="_blank" >10.1111/j.1558-5646.2012.01684.x</a>
Alternative languages
Result language
angličtina
Original language name
Dissecting the genetic architecture of F-1 hybrid sterility in house mice
Original language description
Hybrid sterility as a postzygotic reproductive isolation mechanism has been studied for over 80 years, yet the first identifications of hybrid sterility genes in Drosophila and mouse are quite recent. To study the genetic architecture of F-1 hybrid sterility between young subspecies of house mouse Mus m. domesticus and M. m. musculus, we conducted QTL analysis of a backcross between inbred strains representing these two subspecies and probed the role of individual chromosomes in hybrid sterility using the intersubspecific chromosome substitution strains. We provide direct evidence that the asymmetry in male infertility between reciprocal crosses is conferred by the middle region of M. m. musculus Chr X, thus excluding other potential candidates such asY, imprinted genes, and mitochondrial DNA. QTL analysis identified strong hybrid sterility loci on Chr 17 and Chr X and predicted a set of interchangeable autosomal loci, a subset of which is sufficient to activate the Dobzhansky-Muller
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LD11079" target="_blank" >LD11079: New Mouse Models for Studies on Biomedical Complex Traits and Human Diseases and for Systems Genetics</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Evolution
ISSN
0014-3820
e-ISSN
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Volume of the periodical
66
Issue of the periodical within the volume
11
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
3321-3335
UT code for WoS article
000310477600002
EID of the result in the Scopus database
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