The high-risk corneal regraft model: a justification for tissue matching in humans

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00392147" target="_blank" >RIV/68378050:_____/13:00392147 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/tri.12055" target="_blank" >http://dx.doi.org/10.1111/tri.12055</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tri.12055" target="_blank" >10.1111/tri.12055</a>

Result language
angličtina
Original language name
The high-risk corneal regraft model: a justification for tissue matching in humans
Original language description
Models of high-risk corneal graft rejection involve neovascularization induced via innate immune responses, e.g., suture-mediated trauma. We describe a model of high-risk corneal graft rejection using corneal graft donor-recipient pairing based on a single-antigen disparity. Donor corneas from transgenic mice on B10.BR (H-2k) background, in which hen-egg lysozyme (HEL) as a membrane-bound antigen (mHEL) was expressed under the major histocompatibility complex (MHC) Class I promoter (KLK-mHEL, H-2k), were transplanted into wild type B10.BR recipient mice. Unmanipulated wild type recipient mice rejected KLK-mHEL grafts (39%) slowly over 5060days. Graft rejection incidence was maximized (100%) and tempo accelerated (27days) by priming with HEL-pulsed syngeneic dendritic cells and less so by increasing T-cell precursor frequency. Rejection also reached maximum levels (100%) and tempo (38days) when mice which had rejected a first graft (rejectors') were regrafted, and was associated with in
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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