Mechanistic basis of infertility of mouse intersubspecific hybrids
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00397570" target="_blank" >RIV/68378050:_____/13:00397570 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/13:00397570 RIV/00027162:_____/13:#0001016
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568299/" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568299/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1219126110" target="_blank" >10.1073/pnas.1219126110</a>
Alternative languages
Result language
angličtina
Original language name
Mechanistic basis of infertility of mouse intersubspecific hybrids
Original language description
According to the Dobzhansky-Muller model, hybrid sterility is a consequence of the independent evolution of related taxa resulting in incompatible genomic interactions of their hybrids. The model implies that the incompatibilities evolve randomly, unlessa particular gene or nongenic sequence diverges much faster than the rest of the genome. Here we propose that asynapsis of heterospecific chromosomes in meiotic prophase provides a recurrently evolving trigger for the meiotic arrest of interspecific F1hybrids. We observed extensive asynapsis of chromosomes and disturbance of the sex body in >95% of pachynemas of Mus m. musculus x Mus m. domesticus sterile F1 males. Asynapsis was not preceded by a failure of double-strand break induction, and the rateof meiotic crossing over was not affected in synapsed chromosomes. DNA double-strand break repair was delayed or failed in unsynapsed autosomes, and misexpression of chromosome X and chromosome Y genes was detected in single pachynemas an
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
110
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
"E468"-"E477"
UT code for WoS article
000315209800005
EID of the result in the Scopus database
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