Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00398758" target="_blank" >RIV/68378050:_____/13:00398758 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4049/jimmunol.1202401" target="_blank" >http://dx.doi.org/10.4049/jimmunol.1202401</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4049/jimmunol.1202401" target="_blank" >10.4049/jimmunol.1202401</a>

Result language
angličtina
Original language name
Nonredundant roles of Src-family kinases and Syk in the initiation of B-cell antigen receptor signaling
Original language description
When a BCR on a mature B cell is engaged by its ligand, the cell becomes activated, and the Ab-mediated immune response can be triggered. The initiation of BCR signaling is orchestrated by kinases of the Src and Syk families. However, the proximal BCR-induced phosphorylation remains incompletely understood. According to a model of sequential activation of kinases, Syk acts downstream of Src family kinases (SFKs). In addition, signaling independent of SFKs and initiated by Syk has been proposed. Both hypotheses lack sufficient evidence from relevant B cell models, mainly because of the redundancy of Src family members and the importance of BCR signaling for B cell development. We addressed this issue by analyzing controlled BCR triggering ex vivo on primary murine B cells and on murine and chicken B cell lines. Chemical and Csk-based genetic inhibitor treatments revealed that SFKs are required for signal initiation and Syk activation. In addition, ligand and anti-BCR Ab-induced signalin
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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