Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423030" target="_blank" >RIV/68378050:_____/13:00423030 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1242/jcs.123661" target="_blank" >http://dx.doi.org/10.1242/jcs.123661</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/jcs.123661" target="_blank" >10.1242/jcs.123661</a>

Result language
angličtina
Original language name
Involvement of phosphatidylinositol 4,5-bisphosphate in RNA polymerase I transcription
Original language description
RNA polymerase I (Pol I) transcription is essential for the cell cycle, growth and protein synthesis in eukaryotes. In the present study, we found that phosphatidylinositol 4,5-bisphosphate (PIP2) is a part of the protein complex on the active ribosomalpromoter during transcription. PIP2 makes a complex with Pol I and the Pol I transcription factor UBF in the nucleolus. PIP2 depletion reduces Pol I transcription, which can be rescued by the addition of exogenous PIP2. In addition, PIP2 also binds directly to the pre-rRNA processing factor fibrillarin (Fib), and co-localizes with nascent transcripts in the nucleolus. PIP2 binding to UBF and Fib modulates their binding to DNA and RNA, respectively. In conclusion, PIP2 interacts with a subset of Pol I transcription machinery, and promotes Pol I transcription.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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