Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-Iiduced apoptosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F13%3A00423058" target="_blank" >RIV/68378050:_____/13:00423058 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/scd.2013.0057" target="_blank" >http://dx.doi.org/10.1089/scd.2013.0057</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/scd.2013.0057" target="_blank" >10.1089/scd.2013.0057</a>
Alternative languages
Result language
angličtina
Original language name
Human embryonic and induced pluripotent stem cells express TRAIL receptors and can be sensitized to TRAIL-Iiduced apoptosis
Original language description
Death ligands and their tumor necrosis factor receptor (TNFR) family receptors are the best-characterized and most efficient inducers of apoptotic signaling in somatic cells. In this study, we analyzed whether these prototypic activators of apoptosis arealso expressed and able to be activated in human pluripotent stem cells. We examined human embryonic stem cells (hESC) and human-induced pluripotent stem cells (hiPSC) and found that both cell types express primarily TNF-related apoptosis-inducing ligand (TRAIL) receptors and TNFR1, but very low levels of Fas/CD95. We also found that although hESC and hiPSC contain all the proteins required for efficient induction and progression of extrinsic apoptotic signaling, they are resistant to TRAIL-induced apoptosis. However, both hESC and hiPSC can be sensitized to TRAIL-induced apoptosis by co-treatment with protein synthesis inhibitors such as the anti-leukemia drug homoharringtonine (HHT). HHT treatment led to suppression of cellular FLICE
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP301%2F10%2F1971" target="_blank" >GAP301/10/1971: Expression, signaling and function of Death Receptors in human embryonic stem cells.</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cells and Development
ISSN
1547-3287
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
2964-2974
UT code for WoS article
000327010300005
EID of the result in the Scopus database
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