Fibrillarin from Archaea to human

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455869" target="_blank" >RIV/68378050:_____/15:00455869 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/boc.201400077" target="_blank" >http://dx.doi.org/10.1111/boc.201400077</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/boc.201400077" target="_blank" >10.1111/boc.201400077</a>

Result language
angličtina
Original language name
Fibrillarin from Archaea to human
Original language description
Fibrillarin is an essential protein that is well known as a molecular marker of transcriptionally active RNA polymerase I. Fibrillarin methyltransferase activity is the primary known source of methylation for more than 100 methylated sites involved in the first steps of preribosomal processing and required for structural ribosome stability. High expression levels of fibrillarin have been observed in several types of cancer cells, particularly when p53 levels are reduced, because p53 is a direct negativeregulator of fibrillarin transcription. Here, we show fibrillarin domain conservation, structure and interacting molecules in different cellular processes as well as with several viral proteins during virus infection.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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