Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00457384" target="_blank" >RIV/68378050:_____/15:00457384 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/15:00457384 RIV/00179906:_____/15:10319406
Result on the web
<a href="http://dx.doi.org/10.1371/journal.pone.0119549" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0119549</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0119549" target="_blank" >10.1371/journal.pone.0119549</a>
Alternative languages
Result language
angličtina
Original language name
Characterisation of Mesothelioma-Initiating Cells and Their Susceptibility to Anti-Cancer Agents
Original language description
Malignant mesothelioma (MM) is an aggressive type of tumour causing high mortality. One reason for this paradigm may be the existence of a subpopulation of tumour-initiating cells (TICs) that endow MM with drug resistance and recurrence. The objective ofthis study was to identify and characterise a TIC subpopulation in MM cells, using spheroid cultures, mesospheres, as a model of MM TICs. Mesospheres, typified by the stemness markers CD24, ABCG2 and OCT4, initiated tumours in immunodeficient mice moreefficiently than adherent cells. CD24 knock-down cells lost the sphere-forming capacity and featured lower tumorigenicity. Upon serial transplantation, mesospheres were gradually more efficiently tumrigenic with increased level of stem cell markers. We also show that mesospheres feature mitochondrial and metabolic properties similar to those of normal and cancer stem cells. Finally, we show that mesothelioma-initiating cells are highly susceptible to mitochondrially targeted vitamin E su
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
5
Country of publishing house
US - UNITED STATES
Number of pages
21
Pages from-to
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UT code for WoS article
000353887100002
EID of the result in the Scopus database
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