Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00460150" target="_blank" >RIV/68378050:_____/16:00460150 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/16:00460150 RIV/61389005:_____/16:00460150 RIV/00216208:11160/16:10338232 RIV/00023001:_____/16:00059987
Result on the web
<a href="http://dx.doi.org/10.1152/physiolgenomics.00122.2015" target="_blank" >http://dx.doi.org/10.1152/physiolgenomics.00122.2015</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1152/physiolgenomics.00122.2015" target="_blank" >10.1152/physiolgenomics.00122.2015</a>
Alternative languages
Result language
angličtina
Original language name
Autocrine effects of transgenic resistin reduce palmitate and glucose oxidation in brown adipose tissue
Original language description
Resistin has been originally identified as an adipokine that links obesity to insulin resistance in mice. In our previous studies in spontaneously hypertensive rats (SHR) expressing a nonsecreted form of mouse resistin (Retn) transgene specifically in adipose tissue (SHR-Retn), we have observed an increased lipolysis and serum free fatty acids, ectopic fat accumulation in muscles and insulin resistance. Recently, brown adipose tissue (BAT) has been suggested to play an important role in the pathogenesis of metabolic disturbances. In the current study, we have analyzed autocrine effects of transgenic resistin on BAT glucose and lipid metabolism and mitochondrial function in the SHR-Retn versus nontransgenic SHR controls. We observed that interscapular BAT isolated from SHR-Retn transgenic rats when compared to SHR controls showed a lower relative weight, significantly reduced both basal and insulin stimulated incorporation of palmitate into BAT lipids, and significantly decreased palmitate oxidation and glucose oxidation. Gene expression profiles in BAT identified differentially expressed genes involved in skeletal muscle and connective tissue development, inflammation and MAPK and insulin signaling. These results provide evidence that autocrine effects of resistin attenuate differentiation and activity of BAT and thus may play a role in the pathogenesis of insulin resistance in the rat.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Physiological Genomics
ISSN
1094-8341
e-ISSN
—
Volume of the periodical
48
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
420-427
UT code for WoS article
000378338300005
EID of the result in the Scopus database
2-s2.0-84983770971