SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00471838" target="_blank" >RIV/68378050:_____/16:00471838 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.neuropharm.2016.03.008" target="_blank" >http://dx.doi.org/10.1016/j.neuropharm.2016.03.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.neuropharm.2016.03.008" target="_blank" >10.1016/j.neuropharm.2016.03.008</a>

Result language
angličtina
Original language name
SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner
Original language description
Many diseases of the nervous system are accompanied by alterations in synaptic functions. Synaptic plasticity mediated by the endogenous cannabinoid system involves the activation of the cannabinoid receptor 1 (CB1R). The principles of CB1R signaling must be understood in detail for its therapeutic exploration. We detected the Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 (SGIP1) as a novel CB1R partner. SGIP1 is functionally linked to clathrin-mediated endocytosis and its overexpression in animals leads to an energy regulation imbalance resulting in obesity. We report that SGIP1 prevents the endocytosis of activated CB1R and that it alters signaling via the CB1R in a biased manner. CB1R mediated G-protein activation is selectively influenced by SGIP1, arrestin associated signaling is changed profoundly, most likely as a consequence of the prevention of the receptor's internalization elicited by SGIP1. (C) 2016 The Authors. Published by Elsevier Ltd.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/GAP303%2F12%2F2408" target="_blank" >GAP303/12/2408: Functional Consequences of Metabotropic Glutamate Receptor 1a and 1b Splice Variants Assembly in Heterodimeric Complexes</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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