The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00471894" target="_blank" >RIV/68378050:_____/16:00471894 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/all.12877" target="_blank" >http://dx.doi.org/10.1111/all.12877</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.12877" target="_blank" >10.1111/all.12877</a>
Alternative languages
Result language
angličtina
Original language name
The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma
Original language description
A family of widely expressed ORM-like (ORMDL) proteins has been recently linked to asthma in genomewide association studies in humans and extensively explored in in vivo studies in mice. ORMDL proteins are key regulators of serine palmitoyltransferase, an enzyme catalyzing the initial step of sphingolipid biosynthesis. Sphingolipids play prominent roles in cell signaling and response to stress, and they affect the mechanistic properties of cellular membranes. Deregulation of sphingolipid biosynthesis and their recycling has been proven to support and even cause several diseases including allergy, inflammation, and asthma. ORMDL3, the most extensively studied member of the ORMDL family, has been shown to be important for endoplasmic reticulum homeostasis by regulating the unfolded protein response and calcium response. In immune cells, ORMDL3 is involved in migration and in the production of proinflammatory cytokines. Furthermore, changes in the expression level of ORMDL3 are important in allergen-induced asthma pathologies. This review focuses on functional aspects of the ORMDL family proteins, which may serve as new therapeutic targets for the treatment of asthma and some other life-threatening diseases.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Allergy
ISSN
0105-4538
e-ISSN
—
Volume of the periodical
71
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
23
Pages from-to
918-930
UT code for WoS article
000378280200002
EID of the result in the Scopus database
—