HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00472044" target="_blank" >RIV/68378050:_____/16:00472044 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tranon.2016.01.005" target="_blank" >http://dx.doi.org/10.1016/j.tranon.2016.01.005</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tranon.2016.01.005" target="_blank" >10.1016/j.tranon.2016.01.005</a>

Result language
angličtina
Original language name
HIC1 Expression Distinguishes Intestinal Carcinomas Sensitive to Chemotherapy
Original language description
Neoplastic growth is frequently associated with genomic DNA methylation that causes transcriptional silencing of tumor suppressor genes. We used a collection of colorectal polyps and carcinomas in combination with bioinformatics analysis of large datasets to study the expression and methylation of Hypermethylated in cancer 1 (HIC1), a tumor suppressor gene inactivated in many neoplasms. In premalignant stages, HIC1 expression was decreased, and the decrease was linked to methylation of a specific region in the HIC1 locus. However, in carcinomas, the HIC1 expression was variable and, in some specimens, comparable to healthy tissue. Importantly, high HIC1 production distinguished a specific type of chemotherapy-responsive tumors.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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