Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00472996" target="_blank" >RIV/68378050:_____/16:00472996 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1186/s12864-016-2383-1" target="_blank" >http://dx.doi.org/10.1186/s12864-016-2383-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12864-016-2383-1" target="_blank" >10.1186/s12864-016-2383-1</a>

Result language

angličtina

Original language name

Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster

Original language description

Background: In models extensively used in studies of aging and extended lifespan, such as C. elegans and Drosophila, adult senescence is regulated by gene networks that are likely to be similar to ones that underlie lifespan extension during dormancy. These include the evolutionarily conserved insulin/IGF, TOR and germ line-signaling pathways. Dormancy, also known as dauer stage in the larval worm or adult diapause in the fly, is triggered by adverse environmental conditions, and results in drastically extended lifespan with negligible senescence. It is furthermore characterized by increased stress resistance and somatic maintenance, developmental arrest and reallocated energy resources. In the fly Drosophila melanogaster adult reproductive diapause is additionally manifested in arrested ovary development, improved immune defense and altered metabolism. However, the molecular mechanisms behind this adaptive lifespan extension are not well understood.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

B M C Genomics

ISSN

1471-2164

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

JAN 13

Country of publishing house

US - UNITED STATES

Number of pages

25

Pages from-to

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UT code for WoS article

000368073600003

EID of the result in the Scopus database

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