Intercellular crosstalk in human malignant melanoma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00477963" target="_blank" >RIV/68378050:_____/17:00477963 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/17:10362296 RIV/00064165:_____/17:10362296

Result on the web

<a href="http://dx.doi.org/10.1007/s00709-016-1038-z" target="_blank" >http://dx.doi.org/10.1007/s00709-016-1038-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00709-016-1038-z" target="_blank" >10.1007/s00709-016-1038-z</a>

Result language

angličtina

Original language name

Intercellular crosstalk in human malignant melanoma

Original language description

Incidence of malignant melanoma is increasing globally. While the initial stages of tumors can be easily treated by a simple surgery, the therapy of advanced stages is rather limited. Melanoma cells spread rapidly through the body of a patient to form multiple metastases. Consequently, the survival rate is poor. Therefore, emphasis in melanoma research is given on early diagnosis and development of novel and more potent therapeutic options. The malignant melanoma is arising from melanocytes, cells protecting mitotically active keratinocytes against damage caused by UV light irradiation. The melanocytes originate in the neural crest and consequently migrate to the epidermis. The relationship between the melanoma cells, the melanocytes, and neural crest stem cells manifests when the melanoma cells are implanted to an early embryo: they use similar migratory routes as the normal neural crest cells. Moreover, malignant potential of these melanoma cells is overdriven in this experimental model, probably due to microenvironmental reprogramming. This observation demonstrates the crucial role of the microenvironment in melanoma biology. Indeed, malignant tumors in general represent complex ecosystems, where multiple cell types influence the growth of genetically mutated cancer cells. This concept is directly applicable to the malignant melanoma. Our review article focuses on possible strategies to modify the intercellular crosstalk in melanoma that can be employed for therapeutic purposes.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Protoplasma

ISSN

0033-183X

e-ISSN

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Volume of the periodical

254

Issue of the periodical within the volume

3

Country of publishing house

AT - AUSTRIA

Number of pages

8

Pages from-to

1143-1150

UT code for WoS article

000399037400002

EID of the result in the Scopus database

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