The transcriptional repressor HIC1 regulates intestinal immune homeostasis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00481982" target="_blank" >RIV/68378050:_____/17:00481982 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1038/mi.2017.17" target="_blank" >http://dx.doi.org/10.1038/mi.2017.17</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/mi.2017.17" target="_blank" >10.1038/mi.2017.17</a>

Result language

angličtina

Original language name

The transcriptional repressor HIC1 regulates intestinal immune homeostasis

Original language description

The intestine is a unique immune environment that must respond to infectious organisms but remain tolerant to commensal microbes and food antigens. However, the molecular mechanisms that regulate immune cell function in the intestine remain unclear. Here we identify the POK/ZBTB family transcription factor hypermethylated in cancer 1 (HIC1, ZBTB29) as a central component of immunity and inflammation in the intestine. HIC1 is specifically expressed in immune cells in the intestinal lamina propria (LP) in the steady state and mice with a T-cell-specific deletion of HIC1 have reduced numbers of T cells in the LP. HIC1 expression is regulated by the Vitamin A metabolite retinoic acid, as mice raised on a Vitamin A-deficient diet lack HIC1-positive cells in the intestine. HIC1-deficient T cells overproduce IL-17A in vitro and in vivo, and fail to induce intestinal inflammation, identifying a critical role for HIC1 in the regulation of T-cell function in the intestinal microenvironment under both homeostatic and inflammatory conditions.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Mucosal Immunology

ISSN

1933-0219

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

1518-1528

UT code for WoS article

000413119700013

EID of the result in the Scopus database

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