WIP1 phosphatase as pharmacological target in cancer therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00486774" target="_blank" >RIV/68378050:_____/17:00486774 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s00109-017-1536-2" target="_blank" >http://dx.doi.org/10.1007/s00109-017-1536-2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00109-017-1536-2" target="_blank" >10.1007/s00109-017-1536-2</a>
Alternative languages
Result language
angličtina
Original language name
WIP1 phosphatase as pharmacological target in cancer therapy
Original language description
DNA damage response (DDR) pathway protects cells from genome instability and prevents cancer development. Tumor suppressor p53 is a key molecule that interconnects DDR, cell cycle checkpoints, and cell fate decisions in the presence of genotoxic stress. Inactivating mutations in TP53 and other genes implicated in DDR potentiate cancer development and also influence the sensitivity of cancer cells to treatment. Protein phosphatase 2C delta (referred to as WIP1) is a negative regulator of DDR and has been proposed as potential pharmaceutical target. Until recently, exploitation of WIP1 inhibition for suppression of cancer cell growth was compromised by the lack of selective small-molecule inhibitors effective at cellular and organismal levels. Here, we review recent advances in development of WIP1 inhibitors and discuss their potential use in cancer treatment.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30107 - Medicinal chemistry
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Medicine-Jmm
ISSN
0946-2716
e-ISSN
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Volume of the periodical
95
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
11
Pages from-to
589-599
UT code for WoS article
000402017500004
EID of the result in the Scopus database
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