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WIP1 phosphatase as pharmacological target in cancer therapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00486774" target="_blank" >RIV/68378050:_____/17:00486774 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00109-017-1536-2" target="_blank" >http://dx.doi.org/10.1007/s00109-017-1536-2</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00109-017-1536-2" target="_blank" >10.1007/s00109-017-1536-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    WIP1 phosphatase as pharmacological target in cancer therapy

  • Original language description

    DNA damage response (DDR) pathway protects cells from genome instability and prevents cancer development. Tumor suppressor p53 is a key molecule that interconnects DDR, cell cycle checkpoints, and cell fate decisions in the presence of genotoxic stress. Inactivating mutations in TP53 and other genes implicated in DDR potentiate cancer development and also influence the sensitivity of cancer cells to treatment. Protein phosphatase 2C delta (referred to as WIP1) is a negative regulator of DDR and has been proposed as potential pharmaceutical target. Until recently, exploitation of WIP1 inhibition for suppression of cancer cell growth was compromised by the lack of selective small-molecule inhibitors effective at cellular and organismal levels. Here, we review recent advances in development of WIP1 inhibitors and discuss their potential use in cancer treatment.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30107 - Medicinal chemistry

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2017

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Molecular Medicine-Jmm

  • ISSN

    0946-2716

  • e-ISSN

  • Volume of the periodical

    95

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    11

  • Pages from-to

    589-599

  • UT code for WoS article

    000402017500004

  • EID of the result in the Scopus database