Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00500373" target="_blank" >RIV/68378050:_____/18:00500373 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.3389/fgene.2018.00542" target="_blank" >http://dx.doi.org/10.3389/fgene.2018.00542</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fgene.2018.00542" target="_blank" >10.3389/fgene.2018.00542</a>

Result language

angličtina

Original language name

Bones, Glands, Ears and More: The Multiple Roles of FGF10 in Craniofacial Development

Original language description

Members of the fibroblast growth factor (FGF) family have myriad functions during development of both non-vertebrate and vertebrate organisms. One of these family members, FGF10, is largely expressed in mesenchymal tissues and is essential for postnatal life because of its critical role in development of the craniofacial complex, as well as in lung branching. Here, we review the function of FGF10 in morphogenesis of craniofacial organs. Genetic mouse models have demonstrated that the dysregulation or absence of FGF10 function affects the process of palate closure, and FGF10 is also required for development of salivary and lacrimal glands, the inner ear, eye lids, tongue taste papillae, teeth, and skull bones. Importantly, mutations within the FGF10 locus have been described in connection with craniofacial malformations in humans. A detailed understanding of craniofacial defects caused by dysregulation of FGF10 and the precise mechanisms that underlie them offers new opportunities for development of medical treatments for patients with birth defects and for regenerative approaches for cancer patients with damaged gland tissues.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in genetics

ISSN

1664-8021

e-ISSN

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Volume of the periodical

9

Issue of the periodical within the volume

November

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

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UT code for WoS article

000450537900001

EID of the result in the Scopus database

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