p53 pathway as a target in cancer therapy. Advances in Chemical Biology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00502888" target="_blank" >RIV/68378050:_____/19:00502888 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
p53 pathway as a target in cancer therapy. Advances in Chemical Biology
Original language description
Tumor suppressor p53 is a master regulator of cell proliferation and guardian of the genome integrity. TP53 is the most commonly mutated gene in human cancers. Loss of p53 function leads to genome instability and unrestricted cell proliferation that both contribute to tumor growth. Besides tumor suppressive function, mutant p53 can modulate the behavior of the tumor and its sensitivity to chemotherapy. Induction of wild type p53 leads to tumor regression in mice. Small molecules that reactivate normal p53 function induce tumour cell death and thus p53 pathway is a promising pharmacological target in cancer therapy.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Advances in Chemical Biology
ISBN
978-80-88011-03-3
Number of pages of the result
4
Pages from-to
60-63
Number of pages of the book
210
Publisher name
OPTIO CZ
Place of publication
Praha
UT code for WoS chapter
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