Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00521614" target="_blank" >RIV/68378050:_____/19:00521614 - isvavai.cz</a>
Alternative codes found
RIV/68407700:21230/19:00331070 RIV/00216208:11130/19:10394368
Result on the web
<a href="https://link.springer.com/article/10.1007/s00018-019-03037-0" target="_blank" >https://link.springer.com/article/10.1007/s00018-019-03037-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00018-019-03037-0" target="_blank" >10.1007/s00018-019-03037-0</a>

Result language
angličtina
Original language name
Nuclear pore protein TPR associates with lamin B1 and affects nuclear lamina organization and nuclear pore distribution
Original language description
The organization of the nuclear periphery is crucial for many nuclear functions. Nuclear lamins form dense network at the nuclear periphery and play a substantial role in chromatin organization, transcription regulation and in organization of nuclear pore complexes (NPCs). Here, we show that TPR, the protein located preferentially within the nuclear baskets of NPCs, associates with lamin B1. The depletion of TPR affects the organization of lamin B1 but not lamin A/C within the nuclear lamina as shown by stimulated emission depletion microscopy. Finally, reduction of TPR affects the distribution of NPCs within the nuclear envelope and the effect can be reversed by simultaneous knock-down of lamin A/C or the overexpression of lamin B1. Our work suggests a novel role for the TPR at the nuclear periphery: the TPR contributes to the organization of the nuclear lamina and in cooperation with lamins guards the interphase assembly of nuclear pore complexes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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