Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00522841" target="_blank" >RIV/68378050:_____/19:00522841 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00336C#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/PP/C9PP00336C#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9pp00336c" target="_blank" >10.1039/c9pp00336c</a>

Result language
angličtina
Original language name
Exocyclically metallated tetrapyridinoporphyrazine as a potential photosensitizer for photodynamic therapy
Original language description
We report the first exocyclically metallated tetrapyridinoporphyrazine, [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine-zinc(ii)](NO3)(4) (4), synthesized in a multistep synthesis starting from 3,4-pyridinedicarbonitrile (1). The synthetic procedure involved a platination reaction of the intermediate tetra(3,4-pyrido)porphyrazine-zinc(ii) (2), whereby the zinc(ii) enhanced the solubility of the intermediate enabling the platination reaction. A similar approach to synthesize [tetrakis-(trans-Pt(NH3)(2)Cl)-tetra(3,4-pyrido)porphyrazine](NO3)(4) (5) failed due to the unsuitable solubility properties of the intermediate tetra(3,4-pyrido)porphyrazine (3). The final product 4 and the intermediates were characterized, the photochemical and photophysical properties were determined and the photocytotoxicities were investigated. We demonstrate that the platinated tetra-pyridinoporphyrazine 4 is a potential photosensitizer for photodynamic therapy (PDT).
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy

Project
<a href="/en/project/GA17-02080S" target="_blank" >GA17-02080S: Study of molecular mechanisms involved in suppression of transcription-associated genomic instability</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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