Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523210" target="_blank" >RIV/68378050:_____/19:00523210 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Human stem cell derived disease models for retinitis pigmentosa. Advances in Disease Models
Original language description
Given complexity and health impact of retinitis pigmentosa a better understanding of its pathogenesis is of major importance. Often used research models, such as mouse models, have been shown to insufficiently recapitulate the retinitis pigmentosa phenotype as it is observed in human patients. With the invention of induced pluripotent stem cells and the advances in retinal differentiation in the last decade new possibilities for retinal disease modeling have emerged. Two-dimensional and even three-dimensional in vitro models, known as retinal organoids, have been successfully derived from human stem cells. In this manuscript we describe and discuss the development of these stem cell derived retina models and their applications in retinitis pigmentosa research.
Czech name
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Czech description
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Project
<a href="/en/project/LO1419" target="_blank" >LO1419: Biomodels for Health - Center for model organisms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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