Medaka fish as a model in biomedical vision research

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523251" target="_blank" >RIV/68378050:_____/19:00523251 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Medaka fish as a model in biomedical vision research
Original language description
Medaka (Oryzias latipes) is a small freshwater fish distantly related to the most widely used teleost model organism, zebrafish (Danio rerio). The two teleost fish have become popular models to study various aspects of developmental biology and genetics of the eye. Although the duration of eye development in human, mouse, chick, zebrafish or medaka is vastly different, the sequence of events, the type of embryonic tissues involved and spatiotemporal expression of key regulatory genes is remarkably similar. Medaka mutants constitute a rich resource for studies addressing molecular mechanisms underlying vertebrate eye organogenesis. In addition, recent technological progress, such as implementation of CRISPR/Cas9 approaches, opens up new opportunities for disease modelling. In summary, established state-of-the art molecular and genetic tools make medaka an attractive vertebrate model for future biomedical research, especially as an experimental platform for the development of new clinical tools for the diagnosis and treatment of human disease.
Czech name
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Czech description
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Project
<a href="/en/project/LO1419" target="_blank" >LO1419: Biomodels for Health - Center for model organisms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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