Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00535751" target="_blank" >RIV/68378050:_____/20:00535751 - isvavai.cz</a>

Alternative codes found

RIV/60461373:22340/20:43920744

Result on the web

<a href="https://www.mdpi.com/1422-0067/21/21/7937" target="_blank" >https://www.mdpi.com/1422-0067/21/21/7937</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms21217937" target="_blank" >10.3390/ijms21217937</a>

Result language

angličtina

Original language name

Interleukin-6: Molecule in the Intersection of Cancer, Ageing and COVID-19

Original language description

Interleukin-6 (IL-6) is a cytokine with multifaceted effects playing a remarkable role in the initiation of the immune response. The increased level of this cytokine in the elderly seems to be associated with the chronic inflammatory setting of the microenvironment in aged individuals. IL-6 also represents one of the main signals in communication between cancer cells and their non-malignant neighbours within the tumour niche. IL-6 also participates in the development of a premetastatic niche and in the adjustment of the metabolism in terminal-stage patients suffering from a malignant disease. IL-6 is a fundamental factor of the cytokine storm in patients with severe COVID-19, where it is responsible for the fatal outcome of the disease. A better understanding of the role of IL-6 under physiological as well as pathological conditions and the preparation of new strategies for the therapeutic control of the IL-6 axis may help to manage the problems associated with the elderly, cancer, and serious viral infections.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/ED1.1.00%2F02.0109" target="_blank" >ED1.1.00/02.0109: Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Molecular Sciences

ISSN

1422-0067

e-ISSN

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Volume of the periodical

21

Issue of the periodical within the volume

21

Country of publishing house

CH - SWITZERLAND

Number of pages

25

Pages from-to

7937

UT code for WoS article

000588928900001

EID of the result in the Scopus database

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