Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00538172" target="_blank" >RIV/68378050:_____/20:00538172 - isvavai.cz</a>
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237403" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237403</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0237403" target="_blank" >10.1371/journal.pone.0237403</a>
Alternative languages
Result language
angličtina
Original language name
Dose-dependent regulation of horizontal cell fate by Onecut family of transcription factors
Original language description
Genome duplication leads to an emergence of gene paralogs that are essentially free to undergo the process of neofunctionalization, subfunctionalization or degeneration (gene loss). Onecut1 (Oc1) and Onecut2 (Oc2) transcription factors, encoded by paralogous genes in mammals, are expressed in precursors of horizontal cells (HCs), retinal ganglion cells and cone photoreceptors. Previous studies have shown that ablation of eitherOc1orOc2gene in the mouse retina results in a decreased number of HCs, while simultaneous deletion ofOc1andOc2leads to a complete loss of HCs. Here we study the genetic redundancy betweenOc1andOc2paralogs and focus on how the dose of Onecut transcription factors influences abundance of individual retinal cell types and overall retina physiology. Our data show that reducing the number of functional Oc alleles in the developing retina leads to a gradual decrease in the number of HCs, progressive thinning of the outer plexiform layer and diminished electrophysiology responses. Taken together, these observations indicate that in the context of HC population, the alleles of Oc1/Oc2 paralogous genes are mutually interchangeable, function additively to support proper retinal function and their molecular evolution does not follow one of the typical routes after gene duplication.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/GA18-20759S" target="_blank" >GA18-20759S: The role of Meis homeobox genes in retina development</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
—
Volume of the periodical
15
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
e0237403
UT code for WoS article
000562668300036
EID of the result in the Scopus database
—