Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00539824" target="_blank" >RIV/68378050:_____/20:00539824 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s42003-020-0836-1" target="_blank" >https://www.nature.com/articles/s42003-020-0836-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-020-0836-1" target="_blank" >10.1038/s42003-020-0836-1</a>
Alternative languages
Result language
angličtina
Original language name
Nuclear myosin 1 activates p21 gene transcription in response to DNA damage through a chromatin-based mechanism
Original language description
Nuclear myosin 1 (NM1) has been implicated in key nuclear functions. Together with actin, it has been shown to initiate and regulate transcription, it is part of the chromatin remodeling complex B-WICH, and is responsible for rearrangements of chromosomal territories in response to external stimuli. Here we show that deletion of NM1 in mouse embryonic fibroblasts leads to chromatin and transcription dysregulation affecting the expression of DNA damage and cell cycle genes. NM1 KO cells exhibit increased DNA damage and changes in cell cycle progression, proliferation, and apoptosis, compatible with a phenotype resulting from impaired p53 signaling. We show that upon DNA damage, NM1 forms a complex with p53 and activates the expression of checkpoint regulator p21 (Cdkn1A) by PCAF and Set1 recruitment to its promoter for histone H3 acetylation and methylation. We propose a role for NM1 in the transcriptional response to DNA damage response and maintenance of genome stability.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Communications Biology
ISSN
2399-3642
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
13
Pages from-to
115
UT code for WoS article
000519367600001
EID of the result in the Scopus database
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