The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554522" target="_blank" >RIV/68378050:_____/21:00554522 - isvavai.cz</a>
Result on the web
<a href="https://journals.biologists.com/jcs/article/134/16/jcs258462/271909/The-Bardet-Biedl-syndrome-complex-component-BBS1" target="_blank" >https://journals.biologists.com/jcs/article/134/16/jcs258462/271909/The-Bardet-Biedl-syndrome-complex-component-BBS1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1242/jcs.258462" target="_blank" >10.1242/jcs.258462</a>

Result language
angličtina
Original language name
The Bardet-Biedl syndrome complex component BBS1 controls T cell polarity during immune synapse assembly
Original language description
Components of the intraflagellar transport (IFT) system that regulates the assembly of the primary cilium are co-opted by the non-ciliated T cell to orchestrate polarized endosome recycling and to sustain signaling during immune synapse formation. Here, we investigated the potential role of Bardet-Biedl syndrome 1 protein (BBS1), an essential core component of the BBS complex that cooperates with the IFT system in ciliary protein trafficking, in the assembly of the T cell synapse. We demonstrated that BBS1 allows for centrosome polarization towards the immune synapse. This function is achieved through the clearance of centrosomal F-actin and its positive regulator WASH1 (also known as WASHC1), a process that we demonstrated to be dependent on the proteasome. We show that BBS1 regulates this process by coupling the 19S proteasome regulatory subunit to the microtubule motor dynein for its transport to the centrosome. Our data identify the ciliopathy-related protein BBS1 as a new player in T cell synapse assembly that functions upstream of the IFT system to set the stage for polarized vesicular trafficking and sustained signaling.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/GJ19-03435Y" target="_blank" >GJ19-03435Y: Naïve, memory, and virtual memory T cells in adaptive immune responses</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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