Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554544" target="_blank" >RIV/68378050:_____/21:00554544 - isvavai.cz</a>
Result on the web
<a href="https://www.cell.com/iscience/fulltext/S2589-0042(21)01340-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221013407%3Fshowall%3Dtrue" target="_blank" >https://www.cell.com/iscience/fulltext/S2589-0042(21)01340-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004221013407%3Fshowall%3Dtrue</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.isci.2021.103369" target="_blank" >10.1016/j.isci.2021.103369</a>
Alternative languages
Result language
angličtina
Original language name
Epithelial Wnt secretion drives the progression of inflammation-induced colon carcinoma in murine model
Original language description
Colon cancer is initiated by stem cells that escape the strict control. This process is often driven through aberrant activation of Wnt signaling by mutations in components acting downstream of the receptor complex that unfetter tumor cells from the need for Wnts. Here we describe a class of colon cancer that does not depend on mutated core components of the Wnt pathway. Genetically blocking Wnt secretion from epithelial cells of such tumors results in apoptosis, reduced expression of colon cancer markers, followed by enhanced tumor differentiation. In contrast to the normal colonic epithelium, such tumor cells autosecrete Wnts to maintain their uncontrolled proliferative behavior. In humans, we determined certain cases of colon cancers in which the Wnt pathway is hyperactive, but not through mutations in its core components. Our findings illuminate the path in therapy to find further subtypes of Wnt-dependent colon cancer that might be to Wnt secretion inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA18-21466S" target="_blank" >GA18-21466S: Wnt ligands and Wnt-secreting cells for intestinal homeostasis, regeneration and colon cancer: a complex world beyond the cancer-activating mutation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
iScience
ISSN
2589-0042
e-ISSN
2589-0042
Volume of the periodical
24
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
103369
UT code for WoS article
000740249400010
EID of the result in the Scopus database
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