A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00555977" target="_blank" >RIV/68378050:_____/22:00555977 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10450830
Result on the web
<a href="https://elifesciences.org/articles/71578" target="_blank" >https://elifesciences.org/articles/71578</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7554/eLife.71578" target="_blank" >10.7554/eLife.71578</a>
Alternative languages
Result language
angličtina
Original language name
A model of preferential pairing between epithelial and dendritic cells in thymic antigen transfer
Original language description
Medullary thymic epithelial cells (mTECs), which produce and present self-antigens, are essential for the establishment of central tolerance. Since mTEC numbers are limited, their function is complemented by thymic dendritic cells (DCs), which transfer mTEC-produced self-antigens via cooperative antigen transfer (CAT). While CAT is required for effective T cell selection, many aspects remain enigmatic. Given the recently described heterogeneity of mTECs and DCs, it is unclear whether the antigen acquisition from a particular TEC subset is mediated by preferential pairing with a specific subset of DCs. Using several relevant Cre-based mouse models that control for the expression of fluorescent proteins, we have found that, in regards to CAT, each subset of thymic DCs preferentially targets a distinct mTEC subset(s). Importantly, XCR1(+)-activated DC subset represented the most potent subset in CAT. Interestingly, thymic DCs can also acquire antigens from more than one mTEC, and of these, monocyte-derived dendritic cells (moDCs) were determined to be the most efficient. moDCs also represented the most potent DC subset in the acquisition of antigen from other DCs. These findings suggest a preferential pairing model for the distribution of mTEC-derived antigens among distinct populations of thymic DCs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
eLife
ISSN
2050-084X
e-ISSN
2050-084X
Volume of the periodical
11
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
e71578
UT code for WoS article
000751409900001
EID of the result in the Scopus database
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