Extrathymic expression of Aire controls the induction of effective T(H)17 cell-mediated immune response to Candida albicans
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00559553" target="_blank" >RIV/68378050:_____/22:00559553 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/22:10451180
Result on the web
<a href="https://www.nature.com/articles/s41590-022-01247-6" target="_blank" >https://www.nature.com/articles/s41590-022-01247-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41590-022-01247-6" target="_blank" >10.1038/s41590-022-01247-6</a>
Alternative languages
Result language
angličtina
Original language name
Extrathymic expression of Aire controls the induction of effective T(H)17 cell-mediated immune response to Candida albicans
Original language description
Patients with loss of function in the gene encoding the master regulator of central tolerance AIRE suffer from a devastating disorder called autoimmune polyendocrine syndrome type 1 (APS-1), characterized by a spectrum of autoimmune diseases and severe mucocutaneous candidiasis. Although the key mechanisms underlying the development of autoimmunity in patients with APS-1 are well established, the underlying cause of the increased susceptibility to Candida albicans infection remains less understood. Here, we show that Aire(+)MHCII(+) type 3 innate lymphoid cells (ILC3s) could sense, internalize and present C. albicans and had a critical role in the induction of Candida-specific T helper 17 (T(H)17) cell clones. Extrathymic Rorc-Cre-mediated deletion of Aire resulted in impaired generation of Candida-specific T(H)17 cells and subsequent overgrowth of C. albicans in the mucosal tissues. Collectively, our observations identify a previously unrecognized regulatory mechanism for effective defense responses against fungal infections.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Immunology
ISSN
1529-2908
e-ISSN
1529-2916
Volume of the periodical
23
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
1098-1108
UT code for WoS article
000817057200002
EID of the result in the Scopus database
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