The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00565126" target="_blank" >RIV/68378050:_____/22:00565126 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10451231 RIV/00064165:_____/22:10451231 RIV/00216208:11310/22:10451231
Result on the web
<a href="https://www.mdpi.com/2073-4409/11/22/3698" target="_blank" >https://www.mdpi.com/2073-4409/11/22/3698</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells11223698" target="_blank" >10.3390/cells11223698</a>
Alternative languages
Result language
angličtina
Original language name
The Role of IL-6 in Cancer Cell Invasiveness and Metastasis-Overview and Therapeutic Opportunities
Original language description
Interleukin 6 (IL-6) belongs to a broad class of cytokines involved in the regulation of various homeostatic and pathological processes. These activities range from regulating embryonic development, wound healing and ageing, inflammation, and immunity, including COVID-19. In this review, we summarise the role of IL-6 signalling pathways in cancer biology, with particular emphasis on cancer cell invasiveness and metastasis formation. Targeting principal components of IL-6 signalling (e.g., IL-6Rs, gp130, STAT3, NF-kappa B) is an intensively studied approach in preclinical cancer research. It is of significant translational potential, numerous studies strongly imply the remarkable potential of IL-6 signalling inhibitors, especially in metastasis suppression.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
11
Issue of the periodical within the volume
22
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
23
Pages from-to
3698
UT code for WoS article
000887160100001
EID of the result in the Scopus database
—