Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00566015" target="_blank" >RIV/68378050:_____/22:00566015 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/22:00565105
Result on the web
<a href="https://www.aging-us.com/article/204207/text" target="_blank" >https://www.aging-us.com/article/204207/text</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.18632/aging.204207" target="_blank" >10.18632/aging.204207</a>

Result language
angličtina
Original language name
Synergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells
Original language description
Accumulation of senescent cells in tissues with advancing age participates in the pathogenesis of several human age-associated diseases. Specific senescent secretome, the resistance of senescent cells to apoptotic stimuli, and lack of immune system response contribute to the accumulation of senescent cells and their adverse effects in tissues. Inhibition of antiapoptotic machinery, augmented in senescent cells, by BCL-2 protein family inhibitors represents a promising approach to eliminate senescent cells from tissues. This study aimed to explore synergistic and selective senolytic effects of anti-apoptotic BCL-2 family targeting compounds, particularly BH3 mimetics.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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