DYNAMIC EVOLUTION OF AVIAN RNA VIRUS SENSORS: REPEATED LOSS OF RIG-I AND MDA5

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00567906" target="_blank" >RIV/68378050:_____/22:00567906 - isvavai.cz</a>

Result on the web

<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/37/67" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/37/67</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

DYNAMIC EVOLUTION OF AVIAN RNA VIRUS SENSORS: REPEATED LOSS OF RIG-I AND MDA5

Original language description

Two key cytosolic receptors belonging to the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family detect the viral RNA-derived danger signals: RIG-I and melanoma differentiation-associated protein 5 (MDA5)1. Their activation establishes an antiviral state by downstream signaling that ultimately activates interferon-stimulated genes (ISGs). While in rare casesRIG-I gene loss has been detected in mammalian and avian species, most notably in the chicken,MDA5 pseudogenization has only been detected once in mammals2. We have screened over a hundred publicly available avian genome sequences and described an independent disruption ofMDA5in two unrelated avian lineages, the storks (Ciconiiformes) and the rallids (Gruiformes)3.Further, we detected 14 independent losses oft he RIG-Isensort in various bird species. In almost all cases, the RIG-Iloss was coupled with loss of ist regulatory ubiquitin ligase RIPLET/RNF135.We also used several approaches to assess the compensatory evolution of the remaining RLR sensor in cases of gene loss. Although the MDA5loss does not appear to have resulted in any compensatory evolution in the RIG-Igene, in the reciprocial situation we detect a possible pattern of compensatory evolution in MDA5. These findings provide further support for the dynamic evolution of RLR sensots and propose new questions about the redundancy and flexibility of the RNA virus-sensing apparatus in birds.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10607 - Virology

Project

<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů