Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00571076" target="_blank" >RIV/68378050:_____/23:00571076 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00571076 RIV/00216208:11130/23:10458307 RIV/00216208:11110/23:10458307 RIV/00216208:11140/23:10458307 and 3 more
Result on the web
<a href="https://www.nature.com/articles/s41419-023-05728-w" target="_blank" >https://www.nature.com/articles/s41419-023-05728-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41419-023-05728-w" target="_blank" >10.1038/s41419-023-05728-w</a>

Result language
angličtina
Original language name
Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients
Original language description
While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I IFN production in the tumor microenvironment promotes cancer immunosurveillance and contributes to the efficacy of various antineoplastic agents, notably immunogenic cell death inducers. Here, we report that malignant blasts from patients with acute myeloid leukemia (AML) release type I IFN via a Toll-like receptor 3 (TLR3)-dependent mechanism that is not driven by treatment. While in these patients the ability of type I IFN to stimulate anticancer immune responses was abolished by immunosuppressive mechanisms elicited by malignant blasts, type I IFN turned out to exert direct cytostatic, cytotoxic and chemosensitizing activity in primary AML blasts, leukemic stem cells from AML patients and AML xenograft models. Finally, a genetic signature of type I IFN signaling was found to have independent prognostic value on relapse-free survival and overall survival in a cohort of 132 AML patients. These findings delineate a clinically relevant, therapeutically actionable and prognostically informative mechanism through which type I IFN mediates beneficial effects in patients with AML.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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