A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00573452" target="_blank" >RIV/68378050:_____/23:00573452 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007/s00335-023-09997-w" target="_blank" >https://link.springer.com/article/10.1007/s00335-023-09997-w</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00335-023-09997-w" target="_blank" >10.1007/s00335-023-09997-w</a>
Alternative languages
Result language
angličtina
Original language name
A review of standardized high-throughput cardiovascular phenotyping with a link to metabolism in mice
Original language description
Cardiovascular diseases cause a high mortality rate worldwide and represent a major burden for health care systems. Experimental rodent models play a central role in cardiovascular disease research by effectively simulating human cardiovascular diseases. Using mice, the International Mouse Phenotyping Consortium (IMPC) aims to target each protein-coding gene and phenotype multiple organ systems in single-gene knockout models by a global network of mouse clinics. In this review, we summarize the current advances of the IMPC in cardiac research and describe in detail the diagnostic requirements of high-throughput electrocardiography and transthoracic echocardiography capable of detecting cardiac arrhythmias and cardiomyopathies in mice. Beyond that, we are linking metabolism to the heart and describing phenotypes that emerge in a set of known genes, when knocked out in mice, such as the leptin receptor (Lepr), leptin (Lep), and Bardet–Biedl syndrome 5 (Bbs5). Furthermore, we are presenting not yet associated loss-of-function genes affecting both, metabolism and the cardiovascular system, such as the RING finger protein 10 (Rfn10), F-box protein 38 (Fbxo38), and Dipeptidyl peptidase 8 (Dpp8). These extensive high-throughput data from IMPC mice provide a promising opportunity to explore genetics causing metabolic heart disease with an important translational approach.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mammalian Genome
ISSN
0938-8990
e-ISSN
1432-1777
Volume of the periodical
34
Issue of the periodical within the volume
2
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
107-122
UT code for WoS article
001012256500002
EID of the result in the Scopus database
2-s2.0-85162027607