Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00617303" target="_blank" >RIV/68378050:_____/23:00617303 - isvavai.cz</a>
Result on the web
<a href="https://foliabiologica.lf1.cuni.cz/69/5/0194/" target="_blank" >https://foliabiologica.lf1.cuni.cz/69/5/0194/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/fb2023069050194" target="_blank" >10.14712/fb2023069050194</a>
Alternative languages
Result language
angličtina
Original language name
Many Ways to the Cell Cycle Exit after Inhibition of CDK4/6
Original language description
Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Development of selective CDK4/6 inhibitors including palbociclib revolutionized the treatment of advanced HR+/HER2– breast cancer. Inhibition of CDK4/6 leads to cell cycle arrest in G0/G1 phase and eventually to a permanent cell cycle exit called senescence. One of the main features of the senescence is an increased cell size. For many years, it was believed that the non-dividing cells simply continue to grow and as a result, they become excessively large. There is now emerging evidence that the increased cell size is a cause rather than consequence of the cell cycle arrest. This review aims to summarize recent advances in our understanding of senescence induction, in particular that resulting from treatment with CDK4/6 inhibitors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Biologica
ISSN
0015-5500
e-ISSN
0015-5500
Volume of the periodical
69
Issue of the periodical within the volume
5-6
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
3
Pages from-to
194-196
UT code for WoS article
001199526300003
EID of the result in the Scopus database
2-s2.0-85190398748