Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00585194" target="_blank" >RIV/68378050:_____/24:00585194 - isvavai.cz</a>
Result on the web
<a href="https://academic.oup.com/genetics/article/226/3/iyae004/7529178?login=false" target="_blank" >https://academic.oup.com/genetics/article/226/3/iyae004/7529178?login=false</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/genetics/iyae004" target="_blank" >10.1093/genetics/iyae004</a>
Alternative languages
Result language
angličtina
Original language name
Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.
Original language description
PRDM9-mediated reproductive isolation was first described in the progeny of Mus musculus musculus (MUS) PWD/Ph and Mus musculus domesticus (DOM) C57BL/6J inbred strains. These male F1 hybrids fail to complete chromosome synapsis and arrest meiosis at prophase I, due to incompatibilities between the Prdm9 gene and hybrid sterility locus Hstx2. We identified 14 alleles of Prdm9 in exon 12, encoding the DNA-binding domain of the PRDM9 protein in outcrossed wild mouse populations from Europe, Asia, and the Middle East, 8 of which are novel. The same allele was found in all mice bearing introgressed t-haplotypes encompassing Prdm9. We asked whether 7 novel Prdm9 alleles in MUS populations and the t-haplotype allele in 1 MUS and 3 DOM populations induce Prdm9-mediated reproductive isolation. The results show that only combinations of the dom2 allele of DOM origin and the MUS msc1 allele ensure complete infertility of intersubspecific hybrids in outcrossed wild populations and inbred mouse strains examined so far. The results further indicate that MUS mice may share the erasure of PRDM9msc1 binding motifs in populations with different Prdm9 alleles, which implies that erased PRDM9 binding motifs may be uncoupled from their corresponding Prdm9 alleles at the population level. Our data corroborate the model of Prdm9-mediated hybrid sterility beyond inbred strains of mice and suggest that sterility alleles of Prdm9 may be rare.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GA22-29928S" target="_blank" >GA22-29928S: Reconstituting a minimum hybrid sterility genome</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genetics
ISSN
0016-6731
e-ISSN
1943-2631
Volume of the periodical
226
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
iyae004
UT code for WoS article
001172596200001
EID of the result in the Scopus database
2-s2.0-85187175044