ABIN1 is a negative regulator of effector functions in cytotoxic T cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00601093" target="_blank" >RIV/68378050:_____/24:00601093 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/24:10487537 RIV/00216208:11310/24:10487537
Result on the web
<a href="https://www.embopress.org/doi/full/10.1038/s44319-024-00179-6" target="_blank" >https://www.embopress.org/doi/full/10.1038/s44319-024-00179-6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s44319-024-00179-6" target="_blank" >10.1038/s44319-024-00179-6</a>
Alternative languages
Result language
angličtina
Original language name
ABIN1 is a negative regulator of effector functions in cytotoxic T cells
Original language description
T cells are pivotal in the adaptive immune defense, necessitating a delicate balance between robust response against infections and self-tolerance. Their activation involves intricate cross-talk among signaling pathways triggered by the T-cell antigen receptors (TCR) and co-stimulatory or inhibitory receptors. The molecular regulation of these complex signaling networks is still incompletely understood. Here, we identify the adaptor protein ABIN1 as a component of the signaling complexes of GITR and OX40 co-stimulation receptors. T cells lacking ABIN1 are hyper-responsive ex vivo, exhibit enhanced responses to cognate infections, and superior ability to induce experimental autoimmune diabetes in mice. ABIN1 negatively regulates p38 kinase activation and late NF-kappa B target genes. P38 is at least partially responsible for the upregulation of the key effector proteins IFNG and GZMB in ABIN1-deficient T cells after TCR stimulation. Our findings reveal the intricate role of ABIN1 in T-cell regulation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Reports
ISSN
1469-221X
e-ISSN
1469-3178
Volume of the periodical
25
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
30
Pages from-to
3456-3485
UT code for WoS article
001247899800004
EID of the result in the Scopus database
2-s2.0-85195880915