AVIAN INTERFERON REGULATORY FACTORS (ALMOST) RESOLVED

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00602175" target="_blank" >RIV/68378050:_____/24:00602175 - isvavai.cz</a>
Result on the web
<a href="http://www.ccsss.cz/index.php/ccsss/issue/view/48/87" target="_blank" >http://www.ccsss.cz/index.php/ccsss/issue/view/48/87</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
AVIAN INTERFERON REGULATORY FACTORS (ALMOST) RESOLVED
Original language description
Interferon regulatory factors (IRFs) are transcription factors that play a key role in anti-viral immunity response of vertebrates. After viral RNA is recognized by RIG-I-like receptors (RLR), IRF3 and IRF7 activate expression of IFN-β which is together with other type I interferons responsible for forming ISGF3 complex (formed by STAT1, STAT2 and IRF9). IRF9 protein has two domains, IRF-associated domain (IAD) that binds to STAT2 and DNA binding domain (DBD) that binds in the nucleus with interferon-stimulated response element (ISRE) in promotor of interferon-stimulated genes (ISGs) and activates their expression1,2. These pathways are well described in mammals and some other vertebrates but there is limited information available in birds. Moreover, IRF9 and IRF3 are thought to be missing in birds3even though both of the pathways are functional.
Czech name
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Czech description
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Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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