SMIM20 promotes complex IV biogenesis and Ca 2+signaling in mice heart
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00636850" target="_blank" >RIV/68378050:_____/25:00636850 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.celrep.2025.115723" target="_blank" >https://doi.org/10.1016/j.celrep.2025.115723</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.celrep.2025.115723" target="_blank" >10.1016/j.celrep.2025.115723</a>
Alternative languages
Result language
angličtina
Original language name
SMIM20 promotes complex IV biogenesis and Ca 2+signaling in mice heart
Original language description
Mitochondria are key to cellular energetics, metabolism, and signaling. Their dysfunction is linked to devastating diseases, including mitochondrial disorders, diabetes, neurodegenerative diseases, cardiac disorders, and cancer. Here, we present a knockout mouse model lacking the complex IV assembly factor SMIM20/ MITRAC7. SMIM20-/- mice display cardiac pathology with reduced heart weight and cardiac output. Heart mitochondria present with reduced levels of complex IV associated with increased complex I activity, have altered fatty acid oxidation, and display elevated levels of ROS production. Interestingly, mutant mouse ventricular myocytes show unphysiological Ca2+handling, which can be attributed to the increase in mitochondrial ROS production. Our study presents an example of a tissue-specific phenotype in the context of OXPHOS dysfunction. Moreover, our data suggest a link between complex IV dysfunction and Ca2+ handling at the endoplasmic reticulum through ROS signaling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cell Reports
ISSN
2639-1856
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
19
Pages from-to
115723
UT code for WoS article
001501902100004
EID of the result in the Scopus database
2-s2.0-105005429113