The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00642364" target="_blank" >RIV/68378050:_____/25:00642364 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10495844 RIV/00216208:11120/25:43928197 RIV/60461373:22310/25:43933632 RIV/00064165:_____/25:10495844
Result on the web
<a href="https://doi.org/10.1007/s00418-025-02362-9" target="_blank" >https://doi.org/10.1007/s00418-025-02362-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-025-02362-9" target="_blank" >10.1007/s00418-025-02362-9</a>
Alternative languages
Result language
angličtina
Original language name
The HOX code of human adult fibroblasts reflects their ectomesenchymal or mesodermal origin
Original language description
Fibroblasts, the most abundant cell type in the human body, play crucial roles in biological processes such as inflammation and cancer progression. They originate from the mesoderm or neural-crest-derived ectomesenchyme. Ectomesenchyme-derived fibroblasts contribute to facial formation and do not express HOX genes during development. The expression and role of the HOX genes in adult fibroblasts is not known. We investigated whether the developmental pattern persists into adulthood and under pathological conditions, such as cancer. We collected adult fibroblasts of ectomesenchymal and mesodermal origins from distinct body parts. The isolated fibroblasts were characterised by immunocytochemistry, and their transcriptome was analysed by whole genome profiling. Significant differences were observed between normal fibroblasts from the face (ectomesenchyme) and upper limb (mesoderm), particularly in genes associated with limb development, including HOX genes, e.g., HOXA9 and HOXD9. Notably, the pattern of HOX gene expression remained consistent postnatally, even in fibroblasts from pathological tissues, including inflammatory states and cancer-associated fibroblasts from primary and metastatic tumours. Therefore, the distinctive HOX gene expression pattern can serve as an indicator of the topological origin of fibroblasts. The influence of cell position and HOX gene expression in fibroblasts on disease progression warrants further investigation.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histochemistry and Cell Biology
ISSN
0948-6143
e-ISSN
1432-119X
Volume of the periodical
163
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
38
UT code for WoS article
001441527300001
EID of the result in the Scopus database
2-s2.0-86000771521