Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00644126" target="_blank" >RIV/68378050:_____/25:00644126 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/25:10506516 RIV/00216208:11310/25:10506516 RIV/00064203:_____/25:10506516
Result on the web
<a href="https://doi.org/10.1038/s41467-025-66459-4" target="_blank" >https://doi.org/10.1038/s41467-025-66459-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-025-66459-4" target="_blank" >10.1038/s41467-025-66459-4</a>

Result language
angličtina
Original language name
Imbalance of stem-like and effector T cell states in children with early type 1 diabetes across conventional and regulatory subsets
Original language description
Type 1 diabetes (T1D) is an autoimmune disease caused by the loss of self-tolerance toward insulin-producing pancreatic beta-cells. Its etiology remains incompletely understood but involves dysregulated T cell responses. Here, we perform single-cell transcriptomic analysis of peripheral blood T cells from children newly diagnosed with T1D, the same children after one year, and healthy donors. We observe that children with diabetes show diminished effector and cytotoxic programs and enhanced stemness-associated gene signature across diverse T cell subsets, especially at diagnosis. In parallel, we detect signs of impaired regulatory capacity in regulatory T cells and regulatory TR3-56 cells. These findings are supported by flow cytometry analysis of the same cohort and reanalysis of publicly available datasets. Overall, our results suggest that T1D is associated with impaired T cell effector differentiation and regulatory T cell dysfunction, both of which may contribute to immune imbalance and loss of self-tolerance.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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