Conductivity of natural and modified DNA measured by scanning tunneling microscopy. The effect of sequence, charge and stacking

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F08%3A00313026" target="_blank" >RIV/68378271:_____/08:00313026 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/08:00313026 RIV/61389013:_____/08:00313026 RIV/00216305:26310/08:PU80074

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Conductivity of natural and modified DNA measured by scanning tunneling microscopy. The effect of sequence, charge and stacking

Original language description

The conductivity of DNA covalently bonded to a gold surface was studied by means of the STM technique. The investigations focused on the role of several features of DNA structure, namely the role of the negative charge at the backbone phosphate group andthe related complex effects of counterions, and of the stacking interactions between the bases in Watson-Crick and other types of base pairs. The measurements have indicated that the best conductor is DNA in its biologically most relevant double-stranded form with Watson-Crick base pairs and charged phosphates equilibrated with counterions and water. All the studied modifications, including DNA with non-Watson-Crick base pairs, the abasic form, and especially the form with phosphate charges eliminatedby chemical modifications, lower the conductivity of natural DNA.

Czech name

Vodivost syntetické základní a modifikované DNA měřená skenovacím tunelovacím mikroskopem. Vliv sekvencí, náboje a stekování

Czech description

Byla zkoumána vodivost speciálně upravených sekvencí molekuly DNA. Z výsledků měření byl stanoven především vliv nespárovaných bazí a abasicity na transport náboje molekulou. Byla popsána role cukrové páteře molekuly a negativních nábojů fosfátových skupin v celkovém transportním chování molekulárního systému.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BM - Solid-state physics and magnetism

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2008

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biophysical Chemistry

ISSN

0301-4622

e-ISSN

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Volume of the periodical

138

Issue of the periodical within the volume

1-2

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

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UT code for WoS article

000260662900002

EID of the result in the Scopus database

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