Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F12%3A00383008" target="_blank" >RIV/68378271:_____/12:00383008 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/12:8185 RIV/68378041:_____/12:00383008 RIV/61389013:_____/12:00383008 RIV/00023001:_____/12:00056495
Result on the web
<a href="http://dx.doi.org/10.2147/IJN.S32824" target="_blank" >http://dx.doi.org/10.2147/IJN.S32824</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/IJN.S32824" target="_blank" >10.2147/IJN.S32824</a>
Alternative languages
Result language
angličtina
Original language name
Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
Original language description
The aim of this study was to evaluate the targeting of mesenchymal stem cells labeled with superparamagnetic iron oxide nanoparticles to the site of a spinal cord injury by means of a magnetic implant. We monitored both the distribution and the number ofcells in the lesion site after their intrathecal administration and the effect of the magnetic implant on cell transplantation. The cell distribution correlated with the calculated distribution of magnetic forces exerted on the transplanted cells in thesubarachnoid space and the lesion site. Our results showed that the targeting efficiency can be increased by using magnets that produce spatially modulated stray fields. We suggested a mathematical model of cell targeting kinetics and analyzed those parameters of the magnetic system critical for efficient cell targeting.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10302 - Condensed matter physics (including formerly solid state physics, supercond.)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Nanomedicine
ISSN
1178-2013
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
16 Jul
Country of publishing house
NZ - NEW ZEALAND
Number of pages
12
Pages from-to
3719-3730
UT code for WoS article
000306404400001
EID of the result in the Scopus database
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