DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F13%3A00422698" target="_blank" >RIV/68378271:_____/13:00422698 - isvavai.cz</a>
Alternative codes found
RIV/61388963:_____/13:00422698 RIV/00216305:26310/13:PU104677
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
DNA and RNA charge transport effect of sequence, stacking, structure and Hg incorporation
Original language description
In this work experimental and theoretical approaches have been combined for unique study and comparison of charge transfer efficiency in standard and modified (Hg incorporated) DNA duplexes and DNA/RNA hybrids. Specific mechanism proposed to account forthe on-chain oligonucleotide charge transport is based on polaron formation-charge is transported coherently by long-distance tunneling (superexchange). A key parameter in this approach is how the bridge orbitals of the intervening DNA bases couple the charge donor and acceptor - this is strongly controlled by specific oligomeres structures and conformation. The RNA/DNA system flexibility also improves the conditions for polaron creation and thus may facilitate rapid (coherent) charge transport in the DNA/RNA hybrids.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů