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Proton-induced direct and indirect damage of plasmid DNA

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F15%3A00448614" target="_blank" >RIV/68378271:_____/15:00448614 - isvavai.cz</a>

  • Alternative codes found

    RIV/61389005:_____/15:00448614 RIV/68407700:21340/15:00235108

  • Result on the web

    <a href="http://dx.doi.org/10.1007/s00411-015-0605-6" target="_blank" >http://dx.doi.org/10.1007/s00411-015-0605-6</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s00411-015-0605-6" target="_blank" >10.1007/s00411-015-0605-6</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Proton-induced direct and indirect damage of plasmid DNA

  • Original language description

    Clustered DNA damage induced by 10, 20 and 30 MeV protons in pBR322 plasmid DNA was investigated. Besides determination of strand breaks, additional lesions were detected using base excision repair enzymes. The plasmid was irradiated in dry form, where indirect radiation effects were almost fully suppressed, and in water solution containing only minimal residual radical scavenger. Simultaneous irradiation of the plasmid DNA in the dry form and in the solution demonstrated the contribution of the indirect effect as prevalent. The damage composition slightly differed when comparing the results for liquid and dry samples. The obtained data were also subjected to analysis concerning different methodological approaches, particularly the influence of irradiation geometry, models used for calculation of strand break yields and interpretation of the strand breaks detected with the enzymes. It was shown that these parameters strongly affect the results.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    BO - Biophysics

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Radiation and Environmental Biophysics

  • ISSN

    0301-634X

  • e-ISSN

  • Volume of the periodical

    54

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    DE - GERMANY

  • Number of pages

    10

  • Pages from-to

    343-352

  • UT code for WoS article

    000358328800010

  • EID of the result in the Scopus database

    2-s2.0-84938996562