Structural analysis of nanoparticulate carriers for encapsulation of macromolecular drugs
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F17%3A00483621" target="_blank" >RIV/68378271:_____/17:00483621 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.molliq.2016.11.064" target="_blank" >http://dx.doi.org/10.1016/j.molliq.2016.11.064</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.molliq.2016.11.064" target="_blank" >10.1016/j.molliq.2016.11.064</a>
Alternative languages
Result language
angličtina
Original language name
Structural analysis of nanoparticulate carriers for encapsulation of macromolecular drugs
Original language description
Recently developed macromolecular drugs display strong potential to cure diseases involving genetic components, e.g. Rheumatoid arthritis, diabetes, Alzheimer's disease, Huntington's disease, Duchenne muscular dystrophy, Retinitis pigmentosa, and several types of cancers. Bioavailability and enhanced drug specificity necessitate the preparation of efficient carrier systems for the macromolecular therapeutics. We employ synchrotron small angle X-ray scattering (SAXS) and cryogenic transmission electron microscopy (Cryo-TEM) to study the nano structure formation, macromolecular drug upload, and the topological transformations occurring upon complexation of supercoiled plasmid DNA (encoding for the therapeutic protein brain-derived neurotrophic factor, BDNF) with cationic lipid nanocarrier assemblies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Liquids
ISSN
0167-7322
e-ISSN
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Volume of the periodical
235
Issue of the periodical within the volume
Jun
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
7
Pages from-to
83-89
UT code for WoS article
000402358300013
EID of the result in the Scopus database
2-s2.0-85007607645