Targeting the mTOR signaling pathway utilizing nanoparticles: A critical overview
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00521400" target="_blank" >RIV/68378271:_____/19:00521400 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/19:00508393 RIV/00023001:_____/19:00077655
Result on the web
<a href="http://hdl.handle.net/11104/0306033" target="_blank" >http://hdl.handle.net/11104/0306033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cancers11010082" target="_blank" >10.3390/cancers11010082</a>
Alternative languages
Result language
angličtina
Original language name
Targeting the mTOR signaling pathway utilizing nanoparticles: A critical overview
Original language description
Proteins of the mammalian target of rapamycin (mTOR) signaling axis are overexpressed or mutated in cancers. However, clinical inhibition of mTOR signaling as a therapeutic strategy in oncology shows rather limited progress. Nanoparticle-based mTOR targeted therapy proposes an attractive therapeutic option for various types of cancers. Here, we critically analyze the current literature on the modulation of mTOR activity by nanoparticles, demonstrate the complexity of cellular responses to functionalized nanoparticles, and underline challenges lying in the identification of the molecular mechanisms of mTOR signaling affected by nanoparticles. We propose the idea that subcytotoxic doses of nanoparticles could be relevant for the induction of subcellular structural changes with possible involvement of mTORC1 signaling. The evaluation of the mechanisms of nanoparticle-based mTOR modulation will provide fundamental knowledge which could help in developing efficient nano-therapeutics.n
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10610 - Biophysics
Result continuities
Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cancers (Basel)
ISSN
2072-6694
e-ISSN
—
Volume of the periodical
11
Issue of the periodical within the volume
1
Country of publishing house
CH - SWITZERLAND
Number of pages
18
Pages from-to
1-18
UT code for WoS article
000457233300002
EID of the result in the Scopus database
2-s2.0-85061974155