Diamond aminated with plasma polymer as biocompatible substrate for protein attachment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F19%3A00521839" target="_blank" >RIV/68378271:_____/19:00521839 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Diamond aminated with plasma polymer as biocompatible substrate for protein attachment
Original language description
Nanocrystalline diamond (NCD) films are known as a highly attractive material for biosensing applications due to their unique semiconducting properties. In this study, we investigate the immobilization of bovine serum albumin (BSA) molecules on the surface of flat and nanoporous diamond films terminated by hydrogen, oxygen or amine-containing plasma polymer (thickness 7 nm). GAR-FTIR and XPS measurements confirmed that the concentration of amine-containing bonds after the BSA attachment depends on the NCD surface termination. We found that the amine-containing polymer provides a strong interlink between BSA protein and the NCD film while preserving its globular conformation and probably also its biochemical functionality. This work was supported by Operational Programme Research, Development and Education financed by European Structural and Investment Funds and the Czech Ministry of Education, Youth and Sports (Project No. SOLID21 - CZ.02.1.01/0.0/0.0/16_019/0000760).n
Czech name
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Czech description
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Project
<a href="/en/project/EF16_019%2F0000760" target="_blank" >EF16_019/0000760: Solid State Physics for 21st century</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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