Regulation of NADPH oxidase-mediated superoxide production by acetylation and deacetylation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00546151" target="_blank" >RIV/68378271:_____/21:00546151 - isvavai.cz</a>

Result on the web

<a href="http://hdl.handle.net/11104/0322796" target="_blank" >http://hdl.handle.net/11104/0322796</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fphys.2021.693702" target="_blank" >10.3389/fphys.2021.693702</a>

Result language

angličtina

Original language name

Regulation of NADPH oxidase-mediated superoxide production by acetylation and deacetylation

Original language description

Oral treatment of apolipoprotein E-knockout (ApoE-KO) mice with the putative sirtuin 1 (SIRT1) activator resveratrol led to a reduction of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity in the heart. In contrast, the SIRT1 inhibitor EX527 enhanced the superoxide production in isolated human polymorphonuclear granulocytes. In human monocytic THP-1 cells, phorbol ester-stimulated superoxide production was enhanced by inhibitors of histone deacetylases (HDACs including quisinostat, trichostatin A (TSA), PCI34051, and tubastatin A) and decreased by inhibitors of histone acetyltransferases [such as garcinol, curcumin, and histone acetyltransferase (HAT) Inhibitor II]. These results indicate that protein acetylation and deacetylation may represent crucial mechanisms regulating NADPH oxidase-mediated superoxide production.n

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Physiology

ISSN

1664-042X

e-ISSN

1664-042X

Volume of the periodical

12

Issue of the periodical within the volume

Aug.

Country of publishing house

CH - SWITZERLAND

Number of pages

11

Pages from-to

693702

UT code for WoS article

000716727500001

EID of the result in the Scopus database

2-s2.0-85118755082