Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378271%3A_____%2F21%3A00547183" target="_blank" >RIV/68378271:_____/21:00547183 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0323523" target="_blank" >http://hdl.handle.net/11104/0323523</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fphy.2021.624963" target="_blank" >10.3389/fphy.2021.624963</a>
Alternative languages
Result language
angličtina
Original language name
Radiobiology experiments with ultra-high dose rate laser-driven protons: methodology and state-of-the-art
Original language description
The use of particle accelerators in radiotherapy has significantly changed the therapeutic outcomes for many types of solid tumours. In particular, protons are well known for sparing normal tissues and increasing the overall therapeutic index. Recent studies show that normal tissue sparing can be further enhanced through proton delivery at 100 Gy/s and above, in the so-called FLASH regime. This has generated very significant interest in assessing the biological effects of proton pulses delivered at very high dose rates. Laser-accelerated proton beams have unique temporal emission properties, which can be exploited to deliver Gy level doses in single or multiple pulses at dose rates exceeding by many orders of magnitude those currently used in FLASH approaches. An extensive investigation of the radiobiology of laser-driven protons is therefore not only necessary for future clinical application, but also offers the opportunity of accessing yet untested regimes of radiobiology.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10305 - Fluids and plasma physics (including surface physics)
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Physics
ISSN
2296-424X
e-ISSN
2296-424X
Volume of the periodical
9
Issue of the periodical within the volume
Apr
Country of publishing house
CH - SWITZERLAND
Number of pages
12
Pages from-to
624963
UT code for WoS article
000642239200001
EID of the result in the Scopus database
2-s2.0-85104594063